• Coarse-grained modelling of dna and dna self-assembly
Coarse-grained modelling of dna and dna self-assembly

Coarse-grained modelling of dna and dna self-assembly

This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of strands to form duplexes, the first time such a wide range of properties has been captured by a coarse-grained model. The scope and potential of the model is demonstrated by simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker - the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology. Voir la suite

  • 3642305164

  • Springer Libri